Really Taking the Piss - Calcium Oxalate in Urine Confirms Poisoning via Ethylene Glycol (±x)
Joseph S R de Saram provides thought-provoking insights into Military Intelligence and Law Enforcement, how they operate beyond (as opposed to above) the law, and how their various antics foreseeably lead to the destruction of Fundamental Human Rights. Updates are in progress so check back regularly – verified articles end with √. Please feel free to LIKE and SHARE…
In the above video Acute Renal Failure results from the consumption or poisoning via Ethylene Glycol (“EG”,”antifreeze”).
(a) The presence of Calcium Oxalate crystals which are normally absent from urine is CONCLUSIVE for EG intoxication.
Overdose of Ethylene Glycol
Physician assistants and nurse practitioners use Clinical Advisor for updated medical guidance to diagnose and treat common medical conditions in daily practice...
(b) Additionally the binding of Calcium ions to Oxalic acid causes Hypocalcemia, ie a reduction in calcium ions in the blood, with its own series of issues…
Ethylene Glycol Toxicity – When the Story Does Not Quite Fit
Ethylene glycol poisoning
Ethylene glycol poisoning is poisoning caused by drinking ethylene glycol .  Early symptoms include intoxication , vomiting and abdominal pain .  Later symptoms may include a decreased level of consciousness , headache , and seizures .  Long....
Several toxic alcohols are of medical and toxicological importance; the principal ones include ethanol, ethylene glycol (EG), methanol, and isopropanol. See Alcohol Toxicity...
Over the past few weeks, my supply of food has been dwindling so I have been drinking much more bottled water than usual. The bottled water was obtained by my parents a few months ago.
The food that I have been eating is Kelloggs’ Crunchy Nut Cornflakes from the UK mixed with water, as the milk had run out weeks earlier – nothing risky there on the face of it.
I have had acute problems with my prostate, to the point of extreme pain, as well as nausea and vomiting for some reason, with continual stomach cramps and headaches.
My kidneys have been hurting and I have been feeling dense and work has not been progressing well.
My heart has been extremely painful with continual arrhythmias, a very tight chest and obvious slurred speech during various conversations (recorded).
20170923 081824 PDS and JDS Discussing Contaminated Water
As can be heard I have informed PDS of the issue with the water but as usual the response is one of disinterest or skepticism. I have these type of conversations all the time in which I am made to look like a paranoid fool. Thankfully this is not one of the more irritating ones.
THIS IS A SPECIFIC TECHNIQUE, TO REINFORCE THE CONCEPT THAT ‘JOE IS IMAGINING THINGS’ AND THE RESPONSE IS TYPICALLY A ‘PLAUSIBLE’ EXPLANATION, DESIGNED TO ERODE MY CREDIBILITY FURTHER.
EVERYONE, INCLUDING A FEW LAWYERS IN AU AND GB HAVE BEEN PUSHING THIS TECHNIQUE WITHOUT SUCCESS, AS NO-ONE CAN CHALLENGE THE FORENSICS 🙂
Taking the Piss, Literally
On 07 and 08 December 2017 two samples of my urine were provided to a lab for testing.
Both samples are cloudy, and the one on the left markedly so but it has been in the fridge overnight. However, let us consider the actual lab reports rather than visuals although the abnormal pink colour is obviously not yellow :):-
The existence of Pus Cells
* * EXISTENCE OF CALCIUM OXALATE * *
CONFIRMS ETHYLENE GLYCOL TOXICITY OR ITS EQUIVALENT
both FINDINGS REINFORCE EACH OTHER in relation to POISONOUS SUBSTANCES and their DAMAGING EFFECTS ON MY PHYSICAL HEALTH
Attempted Murder – Not Again 🙂
The following videos are forensic cases in relation to actual murders involving Poisoning via Ethylene Glycol.
As can be heard, the KEY FINDING was CALCIUM OXALATE CRYSTALS and THIS EVIDENCE IS IRREFUTABLE.
“Incoherent, confused, vomiting, hallucinating”
“Coronary Artery Disease’ was incorrectly considered the ‘Cause of Death’.
“Other toxicology tests proved negative”
Medical References and Whitepapers
Ethylene Glycol and Propylene Glycol Toxicity What Are the Stages of Ethylene Glycol Intoxication?
Upon completion of this section, you should be able to explain the mechanism of ethylene glycol toxicity and describe the three stages of ethylene glycol toxicity...
Are calcium oxalate crystals involved in the mechanism of acute renal failure in ethylene glycol poisoning?
Introduction. Ethylene glycol (EG) poisoning often results in acute renal failure, particularly if treatment with fomepizole or ethanol is delayed because of late presentation or diagnosis. The mechanism has not been established but is thought to result from the production of a toxic metabolite.
Methods. A literature review utilizing PubMed identified papers dealing with renal toxicity and EG or oxalate. The list of papers was culled to those relevant to the mechanism and treatment of the renal toxicity associated with either compound. Role of metabolites. Although the “aldehyde” metabolites of EG, glycolaldehyde, and glyoxalate, have been suggested as the metabolites responsible, recent studies have shown definitively that the accumulation of calcium oxalate monohydrate (COM) crystals in kidney tissue produces renal tubular necrosis that leads to kidney failure.
In vivo studies in EG-dosed rats have correlated the severity of renal damage with the total accumulation of COM crystals in kidney tissue. Studies in cultured kidney cells, including human proximal tubule (HPT) cells, have demonstrated that only COM crystals, not the oxalate ion, glycolaldehyde, or glyoxylate, produce a necrotic cell death at toxicologically relevant concentrations.
COM crystal accumulation. In EG poisoning, COM crystals accumulate to high concentrations in the kidney through a process involving adherence to tubular cell membranes, followed by internalization of the crystals.
Mechanism of toxicity. COM crystals have been shown to alter membrane structure and function, to increase reactive oxygen species and to produce mitochondrial dysfunction. These processes are likely to be involved in the mechanism of cell death.
Conclusions. Accumulation of COM crystals in the kidney is responsible for producing the renal toxicity associated with EG poisoning. The development of a pharmacological approach to reduce COM crystal adherence to tubular cells and its cellular interactions would be valuable as this would decrease the renal toxicity not only in late treated cases of EG poisoning, but also in other hyperoxaluric diseases such as primary hyperoxaluria and kidney stone formation.
The cytotoxicity of oxalate, metabolite of ethylene glycol, is due to calcium oxalate monohydrate formation
Oxalate is a minor, but important metabolite of ethylene glycol and has been directly linked with acute and subchronic renal toxicity in ethylene glycol poisoning. Numerous studies have characterized the cytotoxicity of oxalate as including plasma membrane damage and organelle injury. Oxalate has two forms in vivo: oxalate ions and calcium oxalate monohydrate (COM) crystals that readily form in the presence of calcium. The present study was designed to compare the cytotoxicity of the oxalate ion and COM crystals in human and rat cells. In rat red blood cells, the oxalate ion did not increase hemolysis, while COM crystals produced hemolysis with a concentration-dependent increase.
In human proximal tubule (HPT) cells in culture, COM suspensions, at concentrations >3 mM but with no oxalate ion, caused cytotoxicity as evidenced by the release of lactate dehydrogenase (LDH) into media. Cytotoxicity was not observed in HPT cells treated with oxalate solutions that contained no COM because EDTA prevented its formation. The cytotoxic effects of COM to HPT cells were potentiated by acidosis (pH 6.5), but not by glycolate, the major metabolite of ethylene glycol.
The toxicity of COM to HPT cells and to proximal tubule cells from Wistar and F-344 rats, compared using both ethidium homodimer uptake and LDH leakage, increased in human and rat cells in a concentration-dependent manner. Rat cells were more sensitive to COM than HPT cells, but there were no apparent differences between the effects in Wistar cells and F-344 cells. These results demonstrate that COM crystals, and not the oxalate ion, are responsible for the membrane damage and cell death observed in normal human and rat PT cells and suggest that COM accumulation in the kidney is responsible for the renal toxicity associated with ethylene glycol exposure.
The cytotoxicity of oxalate, metabolite of ethylene glycol, is due to calcium oxalate monohydrate formation
Oxalate is a minor, but important metabolite of ethylene glycol and has been directly linked with acute and subchronic renal toxicity in ethylene glycol poisoning. Numerous studies have characterized the cytotoxicity of oxalate as including plasma...
Poisoning with Ethylene Glycol is well-established in Sri Lanka, both from the perspective of attempted suicide as well as attempted murder:-
Acute Kidney Injury, Myocardial Infarction and Death Following Brake Fluid Poisoning; A Case Report
Background: Ethylene glycol is a toxic alcohol which is used in brake fluid, antifreeze, coolants, preservatives and chemical solvents. Ethylene glycol poisoning usually results in depression of the central nervous system, renal insufficiency an...
Background: Ethylene glycol is a toxic alcohol which is used in brake fluid, antifreeze, coolants, preservatives and chemical solvents. Ethylene glycol poisoning usually results in depression of the central nervous system, renal insufficiency and cardiopulmonary compromise, while laboratory findings include metabolic acidosis, increased anion gap, increased osmolar gap and calcium oxalate crystalluria.
Case presentation: A 24-year-old previously healthy person died 13 days after self-ingestion of brake fluid (ethylene glycol). He developed multi-organ failure including acute kidney injury, metabolic acidosis, respiratory failure, myocardial infarction, low Glasgow coma scale, and elevation of liver enzymes. He also developed hypotension for which 3 inotropes were started. He had ST elevation myocardial infarction (STEMI) on day 4 of the poisoning associated with a reduction of ejection fraction of up to 25% with septal anterior wall hypokinesia. He needed intensive care treatment via ventilator and inotropic support. Five cycles of hemodialysis were carried out for acute kidney injury. His autopsy examination revealed sub-endocardial hemorrhages.
[I ALREADY HAVE A LOW EJECTION FRACTION IN THE 50S]
Discussion: Acute kidney injury and metabolic acidosis are frequently seen following ethylene glycol poisoning from brake fluid ingestion. The cardiotoxic effect of its poisoning could be due to multiple microcalcifications of the myocardium. This clinical report highlights the severity and the sequence of events following ethylene glycol poisoning.
Conclusion: STEMI may result following ethylene glycol poisoning in addition to other cardiac effects such as hypotension, tachycardia, myocarditis and ischemic changes in ECG.
Acute renal failure following oxalic acid poisoning: a case report
Oxalic acid poisoning is being recognized as an emerging epidemic in the rural communities of Sri Lanka as it is a component of locally produced household laundry detergents. Herein we describe a case of a 32 year old female, presenting after direct ingestion of oxalic acid. She then went on to develop significant metabolic acidosis and acute renal failure, requiring dialysis. Renal biopsy revealed acute tubulointerstitial nephritis associated with diffuse moderate acute tubular damage with refractile crystals in some of the tubules. The patient symptomatically improved with haemodialysis and renal functions subsequently returned to normal.
AS CAN BE SEEN SRI LANKANS KNOW ABOUT THE EFFECTS OF ETHYLENE GLYCOL. HOWEVER I DO NOT WASH MY CLOTHES OR USE DETERGENTS – I JUST BUY NEW CLOTHES AND SO THE ONLY WAY I CAN BE EXPOSED IS DELIBERATE POISONING 🙂
As I mentioned in this article:-
Harassment Surveillance - Psychological Torture
I have published this series of Articles so that Linkies can see the true extent of Harassment Surveillance in today's world, as well as the degree...
“Gang Stalking is experienced by the Targeted Individual as psychological attack, that is capable of immobilizing and destroying them over time. The covert methods used to harass, persecute, and falsely defame the targets often leave NO EVIDENCE to incriminate the civilian spies.”
“When the target tries to describe what is happening to them, it sounds as if they have had a mental breakdown.”
So when I say “people are poisoning me” I sound like I have a psychological problem or I have ‘paranoid schizophrenia’ – that old chestnut 🙂
However as can be seen
THE FORENSICS PROVIDE IRREFUTABLE EVIDENCE THAT I AM ACTUALLY BEING POISONED !!
and the Ethylene Glycol is the reason for my Acute Renal Failure symptoms, which I am in the process of stabilising rapidly 🙂
ONCE AGAIN MY ANALYSIS OF FORENSIC MATERIAL IS CORRECT, AND I AM NOT BEING PARANOID – HA HA !!
The case continues…
Also in this series:-
Grabbing My Pussy was a Colossal Mistake
Unlike many men, I have a large pussy. It is soft and warm and I play with it all the time which gives me lots of pleasure. Often when I stroke it, it
Acute oxalate nephropathy caused by ethylene glycol poisoning
Ethylene glycol (EG) is a sweet-tasting, odorless organic solvent found in many agents, such as anti-freeze. EG is composed of four organic acids: glycoaldehyde, glycolic acid, glyoxylic acid and oxalic acid in vivo . These metabolites are cellular...
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